Meta-Analysis to Determine if Surgical Resection of the Primary Tumour in the Setting of Stage IV Breast Cancer Impacts on Survival

Introduction The role of primary tumor excision in patients with stage IV breast cancer is unclear. Therefore, a meta-analysis of relevant studies was performed to determine whether surgical excision of the primary tumor enhances oncological outcome in the setting of stage IV breast cancer. Methods...

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Bibliographic Details
Published in:Annals of surgical oncology 2013-09, Vol.20 (9), p.2828-2834
Main Authors: Harris, Elly, Barry, Mitchel, Kell, Malcolm R.
Format: Article
Language:English
Subjects:
Breast Neoplasms - mortality
Breast Neoplasms - surgery
Breast Oncology
Female
Humans
Medicine
Medicine & Public Health
Neoplasm Recurrence, Local - mortality
Neoplasm Staging
Oncology
Prognosis
Review Literature as Topic
Surgery
Surgical Oncology
Survival Rate
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Summary:Introduction The role of primary tumor excision in patients with stage IV breast cancer is unclear. Therefore, a meta-analysis of relevant studies was performed to determine whether surgical excision of the primary tumor enhances oncological outcome in the setting of stage IV breast cancer. Methods A comprehensive search for relevant published trials that evaluated outcomes following excision of the primary tumor in stage IV breast cancer was performed using MEDLINE and available data were cross-referenced. Data were extracted following review of appropriate studies by authors. The primary outcome was overall survival following surgical removal of the primary tumor. Results Data from ten studies included 28,693 patients with stage IV disease of whom 52.8 % underwent excision of the primary carcinoma. Surgical excision of the primary tumor in the setting of stage IV breast cancer was associated with a superior survival at 3 years (40 % (surgery) versus 22 % (no surgery) (odds ratio 2.32, 95 % confidence interval 2.08–2.6, p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-013-2998-2