Eosinophilic esophagitis treated with immunotherapy to dust mites

Animal models have shown that there is an increase in eosinophil counts in the esophagus after a nasal challenge with dust mite and roach allergens.4 To our knowledge, the potential role of immunotherapy to indoor allergens and its effect on EoE have not been reported. The likely explanation was tha...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2013-08, Vol.132 (2), p.503-504
Main Authors: Ramirez, Robert M., MD, Jacobs, Robert L., MD
Format: Article
Language:English
Subjects:
Age
Allergies
Allergy and Immunology
Biopsy
Cross Reactions - immunology
Disease
Enteritis - immunology
Eosinophilia - immunology
Family medical history
Food
Food Hypersensitivity - immunology
Gastritis - immunology
Gastrointestinal Diseases - immunology
Humans
Hypersensitivity - immunology
Immunotherapy
Immunotherapy - methods
Male
Patients
Plant Proteins - immunology
Pollen
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Summary:Animal models have shown that there is an increase in eosinophil counts in the esophagus after a nasal challenge with dust mite and roach allergens.4 To our knowledge, the potential role of immunotherapy to indoor allergens and its effect on EoE have not been reported. The likely explanation was that aeroallergens trapped in postnasal drainage were being swallowed, eliciting a recruitment of eosinophils through direct contact with the lining of the esophagus.2 The possible role of immunotherapy for these patients has been previously presented by Perez et al5 and more recently in a letter to the editor by De Swert et al.3 Our case also suggests that immunotherapy might play a role in treating this disease.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2013.04.053