Widespread distribution of brain dopamine receptors evidenced with I Iodosulpride, a highly selective ligand

The new benzamide derivative ( super(125)I)iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors. On autoradiographic images, D-2 receptors are present not only in well-established dopaminergic areas but also, in a discrete manner, in a number of catecholaminergic region...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1985-05, Vol.228 (4700), p.752-754
Main Authors: Martres, Marie-Pascale, Bouthenet, Marie-Louise, Sales, Nicole, Sokoloff, Perre, Schwartz, Jean-Charles
Format: Article
Language:English
Subjects:
brain
Dopamine
dopamine D2
Laboratory rats
Pharmaceutical research
Physiological aspects
rats
Rats as laboratory animals
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Summary:The new benzamide derivative ( super(125)I)iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors. On autoradiographic images, D-2 receptors are present not only in well-established dopaminergic areas but also, in a discrete manner, in a number of catecholaminergic regions in which the dopaminergic innervation is still unknown, imprecise, or controversial, as in the sensorimotor cerebral cortex or cerebellum. This widespread distribution suggests larger physiological and pathophysiological roles for cerebral dopamine receptors than was previously thought.
ISSN:0036-8075
1095-9203