Involvement of α-klotho, fibroblast growth factor-, vitamin-D- and calcium-sensing receptor in 53 patients with primary hyperparathyroidism

The presentation of patients with primary hyperparathyroidism is often atypical and ranges from normocalcemic, primary hyperparathyroidism to severe, symptomatic hypercalcemia. G-protein-coupled, calcium-sensing receptor (CaSR), vitamin D receptor (VDR), and fibroblast growth factor receptor (FGFR)/...

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Bibliographic Details
Published in:Endocrine 2013-08, Vol.44 (1), p.255-263
Main Authors: Latus, Joerg, Lehmann, Renate, Roesel, Meike, Fritz, Peter, Braun, Niko, Ulmer, Christoph, Steurer, Wolfgang, Biegger, Dagmar, Ott, German, Dippon, Juergen, Alscher, M. Dominik, Kimmel, Martin
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Cohort Studies
Diabetes
Endocrinology
Female
Fibroblast Growth Factors - physiology
Glucuronidase - physiology
Humanities and Social Sciences
Humans
Hyperparathyroidism, Primary - etiology
Hyperparathyroidism, Primary - metabolism
Immunohistochemistry
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Original Article
Receptors, Calcitriol - physiology
Receptors, Calcium-Sensing - physiology
Receptors, Fibroblast Growth Factor - physiology
Science
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Summary:The presentation of patients with primary hyperparathyroidism is often atypical and ranges from normocalcemic, primary hyperparathyroidism to severe, symptomatic hypercalcemia. G-protein-coupled, calcium-sensing receptor (CaSR), vitamin D receptor (VDR), and fibroblast growth factor receptor (FGFR)/klotho complexes seem to be involved in the development of pHPT. Parathyroid glands from 53 patients with pHPT and normal parathyroid tissue from 7 patients were obtained during parathyroidectomy. Conventional detailed morphological and immunohistochemical analyses of parathyroid glands were performed after dividing each slide in a 3 × 3 array. From morphology, the number of lipocytes was significantly lower in parathyroid tissue glands in the pHPT group ( p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-013-9881-6