Addition of Vardenafil into Storage Solution Protects the Endothelium in a Hypoxia-Reoxygenation Model

Objective Based upon the well known protective effect of intracellular cyclic guanosine monophosphate (cGMP) accumulation, we tested the hypothesis that storage solution enriched with optimal concentration of the phosphodiestherase-5 inhibitor vardenafil could provide better protection of vascular g...

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Bibliographic Details

Published in:	European journal of vascular and endovascular surgery 2013-08, Vol.46 (2), p.242-248
Main Authors:	Veres, G, Hegedűs, P, Barnucz, E, Zöller, R, Radovits, T, Korkmaz, S, Kolonics, F, Weymann, A, Karck, M, Szabó, G
Format:	Article
Language:	eng
Subjects:	Animals Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Aorta, Thoracic - physiopathology Aorta, Thoracic - transplantation Apoptosis - drug effects cGMP Cold Ischemia Cyclic GMP - metabolism Cytoprotection DNA Damage Dose-Response Relationship, Drug Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Endothelium, Vascular - transplantation Gene Expression Regulation - drug effects Imidazoles - pharmacology Ischaemia-reperfusion injury Male Organ Preservation - methods Organ Preservation Solutions - pharmacology Phosphodiesterase 5 Inhibitors - pharmacology Piperazines - pharmacology Rats Rats, Sprague-Dawley Reperfusion Injury - etiology Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control Storage Sulfones - pharmacology Surgery Time Factors Triazines - pharmacology Vardenafil Vardenafil Dihydrochloride Vascular Grafting - adverse effects Vascular System Injuries - etiology Vascular System Injuries - metabolism Vascular System Injuries - pathology Vascular System Injuries - physiopathology Vascular System Injuries - prevention & control Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilator Agents - pharmacology
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