Histomorphometric evaluation of the coronary artery vessels in rats submitted to industrial noise

Introduction Industrial noise (IN) is characterized by high intensity and a wide spectrum of wavelengths that induce physical vibration on the body structures. This eff ect, resulting from the low-frequency sound waves, can lead to pathological alterations in the extracellular matrix with an abnorma...

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Bibliographic Details
Published in:Acta Cardiologica 2013-06, Vol.68 (3), p.285-289
Main Authors: Antunes, Eduardo, Oliveira, Pedro, Oliveira, Maria João R., Brito, José, Águas, Artur, Martins Dos Santos, José
Format: Article
Language:English
Subjects:
Animals
Coronary Artery Disease - etiology
Coronary Artery Disease - pathology
coronary histomorphometric analysis
Coronary Vessels - pathology
Coronary Vessels - radiation effects
Disease Models, Animal
Fibrosis - etiology
Fibrosis - pathology
Image Processing, Computer-Assisted
Industrial noise
Industry
low frequency noise
Microscopy - methods
Noise, Occupational - adverse effects
perivascular fibrosis
Rats
Rats, Wistar
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Summary:Introduction Industrial noise (IN) is characterized by high intensity and a wide spectrum of wavelengths that induce physical vibration on the body structures. This eff ect, resulting from the low-frequency sound waves, can lead to pathological alterations in the extracellular matrix with an abnormal proliferation of collagen and development of tissue fi brosis, in the absence of an infl ammatory process. Objective The aim of this study was to evaluate the modifi cations of the arterial coronary vessels in Wistar rats submitted to IN. Methods Two groups of rats were considered: group A with 20 rats exposed to IN during a maximum period of 7 months; group B with 20 rats as age-matched controls. The hearts were sectioned from the ventricular apex to the atria and the mid-ventricular fragment was selected. Haematoxylin-eosin and Masson's trichrome staining were used for histological observation. Histomorphometric evaluation of the coronary vessels was performed using the computer image analysis Image J software. The mean lumen-to-vessel wall (L/W) and media vessel wall-to-perivascular tissue (W/P) ratios were calculated sin each group. Results Histological evaluation showed a prominent perivascular tissue with fi brotic development in the absence of infl ammatory cells in group A. Histomorphometric analysis showed that the mean L/W was 0.7297 and 0.6940 in group A and B, respectively. The mean W/P ratio was 0.4923 and 0.5540 in group A and B, respectively, being higher in the control group (P < 0.01). Conclusions There are perivascular structural modifi cations in arterial coronary vessels. Our results show a signifi cant development of periarterial fi brosis induced by industrial noise in the rat heart.
ISSN:0001-5385
1784-973X
0373-7934
DOI:10.1080/AC.68.3.2983423