MMP-2 −1306C > T polymorphism in breast cancer: a case–control study in a South European population

This case control study aims to investigate the role of MMP - 2 − 1306C  >  T polymorphism as a potential risk factor and possible prognostic marker for breast cancer in a South European population. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy co...

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Bibliographic Details
Published in:Molecular biology reports 2013-08, Vol.40 (8), p.5035-5040
Main Authors: Zagouri, Flora, Sergentanis, Theodoros N., Gazouli, Maria, Dimitrakakis, Constantine, Tsigginou, Alexandra, Papaspyrou, Irene, Chrysikos, Dimosthenis, Lymperi, Maria, Zografos, George C., Antsaklis, Aris, Dimopoulos, Meletios-Athanassios, Papadimitriou, Christos A.
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Breast cancer
Breast Neoplasms - genetics
Case-Control Studies
Female
Gene Frequency
Genetic Markers - genetics
Genetic Predisposition to Disease - genetics
Genotype
Genotype & phenotype
Greece
Histology
Humans
Kaplan-Meier Estimate
Life Sciences
Logistic Models
Matrix Metalloproteinase 2 - genetics
Molecular biology
Morphology
Polymorphism
Polymorphism, Single Nucleotide - genetics
Population genetics
Risk factors
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Summary:This case control study aims to investigate the role of MMP - 2 − 1306C  >  T polymorphism as a potential risk factor and possible prognostic marker for breast cancer in a South European population. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy controls were recruited. MMP - 2 − 1306C  >  T polymorphism was genotyped; multivariate logistic regression as well as Cox regression analysis were performed. MMP-2 −1306C > T status was not associated with breast cancer risk either at the total sample or at the subanalyses on premenopausal and postmenopausal women. At the survival analysis, a trend towards a favorable association between MMP-2 −1306C > T allele and disease-free survival as well as overall survival was observed. Regarding subanalyses on ER-negative and ER-positive cases, the favorable association implicating MMP-2 −1306C > T allele was particularly evident among ER-positive cases; no significant associations emerged among ER-negative cases. MMP-2 −1306C > T polymorphism does not seem to be a risk factor for breast cancer in South European population; however, a trend towards a favorable association with survival has been observed.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-013-2604-5