Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index

The aim of this study was to evaluate the inflammatory and oxidative biomarkers’ levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyce...

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Bibliographic Details
Published in:Inflammation 2013-02, Vol.36 (1), p.226-231
Main Authors: Piva, Sílvia Juliane, Tatsch, Etiane, De Carvalho, José Antonio Mainardi, Bochi, Guilherme Vargas, Kober, Helena, Duarte, Thiago, Duarte, Marta Maria Medeiros Frescura, da Cruz, Ivana Beatrice Mânica, Moretto, Maria Beatriz, Moresco, Rafael Noal
Format: Article
Language:English
Subjects:
Albuminuria
Apolipoproteins - blood
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Blood Glucose
Body Mass Index
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Creatinine - blood
Female
Glomerular Filtration Rate
Humans
Immunology
Inflammation - complications
Interleukin-6 - blood
Internal Medicine
Male
Middle Aged
Nitric Oxide - blood
Obesity - blood
Obesity - complications
Obesity - physiopathology
Oxidative Stress
Pathology
Pharmacology/Toxicology
Rheumatology
Serum Albumin
Triglycerides - blood
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Summary:The aim of this study was to evaluate the inflammatory and oxidative biomarkers’ levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 ( r  = 0.326, P  = 0.002), NOx ( r  = −0.249, P  = 0.021), urinary albumin ( r  = 0.270, P  = 0.008), and IMA ( r  = 0.286, P  = 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-012-9538-2