An isolated penile mass in a young adult turned out to be a primary marginal zone lymphoma of the penis. A case report and a review of literature

to discuss the rationale of the management of penile MALT lymphoma. A 24-year-old patient presented with a painless and mobile nodule localized in the ventral part of the penis. The lesion was firstly evaluated through Doppler ultrasonography, which showed a hypoechoic and vascularized solid mass, a...

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Published in:Anticancer research 2013-06, Vol.33 (6), p.2639-2642
Main Authors: Gentile, Giorgio, Broccoli, Alessandro, Brunocilla, Eugenio, Schiavina, Riccardo, Borghesi, Marco, Romagnoli, Daniele, Bianchi, Lorenzo, Derenzini, Enrico, Agostinelli, Claudio, Franceschelli, Alessandro, Colombo, Fulvio, Zinzani, Pier Luigi
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal, Murine-Derived - therapeutic use
Antineoplastic Agents - therapeutic use
Humans
Lymphoma, B-Cell, Marginal Zone - diagnosis
Lymphoma, B-Cell, Marginal Zone - diagnostic imaging
Lymphoma, B-Cell, Marginal Zone - drug therapy
Lymphoma, B-Cell, Marginal Zone - surgery
Male
Organ Sparing Treatments
Penile Neoplasms - diagnosis
Penile Neoplasms - diagnostic imaging
Penile Neoplasms - drug therapy
Penile Neoplasms - surgery
Penis - pathology
Penis - surgery
Radiography
Rituximab
Young Adult
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Summary:to discuss the rationale of the management of penile MALT lymphoma. A 24-year-old patient presented with a painless and mobile nodule localized in the ventral part of the penis. The lesion was firstly evaluated through Doppler ultrasonography, which showed a hypoechoic and vascularized solid mass, a subsequent magnetic resonance confirmed size and position of the lesion. Subsequently the patient underwent a surgical excision of the mass, the pathological diagnosis was consistent with penile lymphoma, MALT-type. The patient underwent a consolidative immunotherapy with rituximab. Disease re-staging was performed through a MR without any detection of local or systemic recurrences. To our knowledge, no cases of MALT lymphoma involving the penis have been reported in the literature so far. Surgical excision with organ sparing and immunotherapy with rituximab, successfully induced a complete response. Based upon this experience, we may recommend a conservative surgery associated with a systemic approach.
ISSN:0250-7005
1791-7530