Transient thyrotoxicosis from thyroiditis induced by sibutramine overdose: A case report

Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The 99mTechnetium-pertechnetate thyroid scan sh...

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Bibliographic Details
Published in:Human & experimental toxicology 2013-08, Vol.32 (8), p.890-892
Main Authors: Kim, SK, Lee, SM, Yoo, SS, Hahm, JR, Jung, JH, Kim, HS, Kim, S, Chung, SI, Jung, TS
Format: Article
Language:English
Subjects:
Adult
Anti-Obesity Agents - toxicity
Biological and medical sciences
Cyclobutanes - toxicity
Drug intoxications. Doping
Drug Overdose
Endocrinopathies
Humans
Male
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pharmaceuticals
Pharmacology. Drug treatments
Serotonin
Thyroid gland
Thyroid. Thyroid axis (diseases)
Thyroiditis - chemically induced
Thyrotoxicosis - chemically induced
Toxicity
Toxicology
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Summary:Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The 99mTechnetium-pertechnetate thyroid scan showed irregular uptake of radioisotope and thyroid-stimulating hormone receptor antibody and thyroperoxidase antibody were negative. Thyroid function normalized after that. The patient had transient thyrotoxicosis with thyroiditis. We report a case of thyrotoxicosis accompanied by thyroiditis resulting from the intentional overdose of sibutramine.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327112468907