High Prevalence of Vertebral Fractures Assessed by Quantitative Morphometry in Hemodialysis Patients, Strongly Associated with Vascular Calcifications

Few studies have provided information on the prevalence of vertebral fractures (VFs) and their risk factors in hemodialysis patients. A multicenter, cross-sectional, observational study was carried out to assess the prevalence of VFs and vascular calcifications (VCs) in 387 hemodialysis patients (me...

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Bibliographic Details
Published in:Calcified tissue international 2013-07, Vol.93 (1), p.39-47
Main Authors: Fusaro, Maria, Tripepi, Giovanni, Noale, Marianna, Vajente, Nicola, Plebani, Mario, Zaninotto, Martina, Guglielmi, Giuseppe, Miotto, Diego, Carbonare, Luca Dalle, D’Angelo, Angela, Ciurlino, Daniele, Puggia, Riccarda, Miozzo, Davide, Giannini, Sandro, Gallieni, Maurizio
Format: Article
Language:English
Subjects:
Adult
Aged
Aorta, Abdominal - pathology
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cross-Sectional Studies
Endocrinology
Epidemiology
Female
Fractures
Hemodialysis
Humans
Iliac Artery - pathology
Life Sciences
Male
Middle Aged
Original Research
Orthopedics
Osteoporosis
Prevalence
Renal Dialysis
Risk factors
Spinal Fractures - epidemiology
Spinal Fractures - etiology
Vascular Calcification - complications
Vascular Calcification - pathology
Vertebrae
Vitamin D
Vitamin D - blood
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Summary:Few studies have provided information on the prevalence of vertebral fractures (VFs) and their risk factors in hemodialysis patients. A multicenter, cross-sectional, observational study was carried out to assess the prevalence of VFs and vascular calcifications (VCs) in 387 hemodialysis patients (mean age 64.2 ± 14.1 years, 63 % males) and in a control group of 51 osteoporotic subjects. Biochemical tests included 25(OH) vitamin D, bone Gla protein (total and undercarboxylated), and total matrix Gla protein. Vertebral quantitative morphometry was carried out centrally for the detection of VF, defined as reduction by ≥20 % of one of the vertebral body dimensions. In the same radiograph, aortic and iliac VC scores were calculated. Prevalence of VF was 55.3 % in hemodialysis patients and 51.0 % in the control group. Multivariate analysis disclosed that male gender (59.8 vs. 47.6 %, p  = 0.02; OR = 1.78, 95 % CI 1.15–2.75) and age (mean ± SD 66.7 ± 13.1 vs. 61.0 ± 14.7 years, p  
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-013-9722-x