Coenzyme Q10 supplementation and diastolic heart functions in hemodialysis patients: A randomized double-blind placebo-controlled trial

Coenzyme Q10 (CoQ10) supplementation has been shown to improve diastolic heart function in various patient cohorts. Systolic and diastolic dysfunctions are common in patients with end‐stage renal disease. Favorable effects of CoQ10 on cardiac functions are yet to be seen in hemodialysis patients. We...

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Bibliographic Details
Published in:Hemodialysis international 2013-07, Vol.17 (3), p.374-381
Main Authors: Turk, Suleyman, Baki, Aysegul, Solak, Yalcin, Kayrak, Mehmet, Atalay, Huseyin, Gaipov, Abduzhappar, Aribas, Alpay, Akilli, Hakan, Biyik, Zeynep, Okudan, Nilsel, Gokbel, Hakki
Format: Article
Language:English
Subjects:
Coenzyme Q10
Cohort Studies
Cross-Over Studies
Diastole - drug effects
diastolic heart function
Double-Blind Method
echocardiography
Echocardiography, Doppler
Female
Heart - drug effects
Heart - physiopathology
hemodialysis
Humans
Kidney Failure, Chronic - diagnostic imaging
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - therapy
Male
Middle Aged
Placebos
Prospective Studies
Renal Dialysis - methods
Ubiquinone - administration & dosage
Ubiquinone - analogs & derivatives
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Summary:Coenzyme Q10 (CoQ10) supplementation has been shown to improve diastolic heart function in various patient cohorts. Systolic and diastolic dysfunctions are common in patients with end‐stage renal disease. Favorable effects of CoQ10 on cardiac functions are yet to be seen in hemodialysis patients. We aimed to evaluate effect of CoQ10 supplementation on diastolic function in a cohort of maintenance hemodialysis patients. This was a prospective, double‐blind, placebo‐controlled, crossover study in which all patients received placebo and oral CoQ10 200 mg/d during the 8 weeks in each phase, with a 4‐week washout period. Participants underwent conventional and tissue Doppler echocardiography before and after each study phase. Parameters characterizing left ventricle diastolic function and other standard echocardiographic measurements were recorded. Twenty‐eight patients were randomized, but 22 patients completed study protocol. Intraventricular septum (IVS) thickness and left ventricle mass were significantly decreased in CoQ10 group (P = 0.03 and P = 0.01, respectively). Myocardial peak systolic and early diastolic velocities derived from IVS were significantly increased (P = 0.048 and P = 0.04, respectively). Isovolumetric relaxation time and E/Em ratio calculated for IVS also significantly reduced in CoQ10 group (p = 0.02 and p = 0.04, respectively). There was no significant difference in any of the studied echocardiographic parameters in placebo group. The results of this study showed that CoQ10 supplementation did not significantly improved diastolic heart functions compared with placebo in maintenance hemodialysis patients.
ISSN:1492-7535
1542-4758
DOI:10.1111/hdi.12022