The value of spectrophotometric intracutaneous analysis in the noninvasive diagnosis of nonmelanoma skin cancers

Summary Background.  Spectrophotometric intracutaneous analysis (SIAscopy) is a recently introduced, noninvasive, rapid and practical method for monitoring pigmented lesions, which calculates the amount of collagen, melanin and haemoglobin deep in the papillary dermis. Aim.  To evaluate the value of...

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Bibliographic Details
Published in:Clinical and experimental dermatology 2013-07, Vol.38 (5), p.464-469
Main Authors: Hacioglu, S., Saricaoglu, H., Baskan, E. B., Uner, S. I., Aydogan, K., Tunali, S.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Collagen - analysis
Dermoscopy - methods
Diagnosis, Differential
Female
Hemoglobins - analysis
Humans
Male
Melanins - analysis
Middle Aged
Observer Variation
Predictive Value of Tests
Sensitivity and Specificity
Skin Neoplasms - chemistry
Skin Neoplasms - diagnosis
Spectrophotometry - methods
Young Adult
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Summary:Summary Background.  Spectrophotometric intracutaneous analysis (SIAscopy) is a recently introduced, noninvasive, rapid and practical method for monitoring pigmented lesions, which calculates the amount of collagen, melanin and haemoglobin deep in the papillary dermis. Aim.  To evaluate the value of SIAscopy in the diagnosis of nonmelanoma skin cancers (NMSC). Methods.  In total, 80 lesions of 76 patients were clinically evaluated by the first investigator, and the data recorded. Eight months after the clinical evaluation, all lesions were evaluated again by the same investigator, using images (SIAgraphs) obtained by the SIAscope. All SIAgraphs were also evaluated by a second investigator, and all dermatoscopic images by a third, independently of each other. All diagnoses were compared with histopathological diagnoses. Results.  The clinical diagnosis was calculated to have a sensitivity of 79% and specificity of 84%. The SIAscopic diagnoses of the first and second investigators had a sensitivity of 55% and 93%, and a specificity of 88% and 53%, respectively, while the dermatoscopic diagnoses of the third investigator had a sensitivity of 86% and specificity of 80%. There was no statistical accordance between the first and second investigators according to the accuracy of SIAscopic diagnoses (P 
ISSN:0307-6938
1365-2230
DOI:10.1111/j.1365-2230.2012.04460.x