Sulfur-containing amino acids in 7TMRs: molecular gears for pharmacology and function

Highlights • 7TMRs contain a large number of sulfur–sulfur and sulfur–aromatic interactions. • Met and Cys residues of 7TMRs govern important signaling and functional events. • Met–arene interactions stabilize 7TMR states related to specific signaling pathways. • Met–arene interactions tune the orie...

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Bibliographic Details

Published in:	Trends in pharmacological sciences (Regular ed.) 2013-06, Vol.34 (6), p.320-331
Main Authors:	Cordomí, Arnau, Gómez-Tamayo, José C, Gigoux, Véronique, Fourmy, Daniel
Format:	Article
Language:	English
Subjects:	Advanced Basic Science Amino Acid Sequence Amino Acids, Sulfur - metabolism Animals crystal structure GPCR Humans Molecular Docking Simulation molecular modeling Molecular Sequence Data Protein Interaction Domains and Motifs Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism site-directed mutagenesis
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