Phagocytosis and intracellular degradation of super(125)I-labelled immune complexes by clofazimine treated macrophage cultures

Mouse peritoneal and calf alveolar macrophage cultures were exposed to various Clofazimine concentrations for 5 days. Cultures exposed to drug concentrations near the blood therapeutic level phagocytize and digest more immune complexes than control cultures. Our results allow us to suggest that the...

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Bibliographic Details
Published in:Clinical and experimental immunology 1982-01, Vol.48 (1), p.268-272
Main Authors: Sarracent, J, Finlay, C M
Format: Article
Language:English
Online Access:Get full text
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Summary:Mouse peritoneal and calf alveolar macrophage cultures were exposed to various Clofazimine concentrations for 5 days. Cultures exposed to drug concentrations near the blood therapeutic level phagocytize and digest more immune complexes than control cultures. Our results allow us to suggest that the beneficial action of Clofazimine in lepromatous leprosy could be at least partially mediated by the removal and degradation of circulating immune complexes by macrophages.
ISSN:0009-9104