Impact of lymphovascular invasion on oncological outcomes in patients with upper tract urothelial carcinoma after radical nephroureterectomy

Objectives To assess the impact of lymphovascular invasion (LVI) on upper urinary tract urothelial carcinomas (UTUCs) in a multicentre study on cancer‐specific survival (CSS), recurrence‐free survival and metastasis‐free survival (MFS). To show the negative impact of LVI for patients with pN0/x dise...

Full description

Saved in:
Bibliographic Details
Published in:BJU international 2013-06, Vol.111 (8), p.1199-1207
Main Authors: Hurel, Sophie, Rouprêt, Morgan, Ouzzane, Adil, Rozet, François, Xylinas, Evanguelos, Zerbib, Marc, Berod, Alexis Arvin, Ruffion, Alain, Adam, Emilie, Cussenot, Olivier, Houlgatte, Alain, Phé, Véronique, Nouhaud, François‐Xavier, Bensadoun, Henri, Delage, Francky, Guillotreau, Julien, Guy, Laurent, Karsenty, Gilles, De La Taille, Alexandre, Colin, Pierre
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Transitional Cell - mortality
Carcinoma, Transitional Cell - secondary
Carcinoma, Transitional Cell - surgery
Female
Follow-Up Studies
France - epidemiology
Humans
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Lymph Node Excision
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic Metastasis
lymphovascular invasion
Male
Medical sciences
Metastasis
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Multivariate analysis
Nephrectomy - methods
Nephrology. Urinary tract diseases
nephroureterectomy
Patients
Pelvis
Prognosis
Proportional Hazards Models
renal pelvis
Retrospective Studies
survival
Survival Rate - trends
Tumors
Tumors of the urinary system
ureter
Ureter - surgery
Ureteral Neoplasms - mortality
Ureteral Neoplasms - pathology
Ureteral Neoplasms - surgery
Urinary tract. Prostate gland
urothelial carcinoma
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives To assess the impact of lymphovascular invasion (LVI) on upper urinary tract urothelial carcinomas (UTUCs) in a multicentre study on cancer‐specific survival (CSS), recurrence‐free survival and metastasis‐free survival (MFS). To show the negative impact of LVI for patients with pN0/x disease and to stratify these patients into risk groups for metastatic relapse. Patients and Methods A multicentre retrospective study was performed on patients who underwent radical nephroureterectomy between 1995 and 2010. LVI status was evaluated as a prognostic factor for survival using univariate and multivariate Cox regression analysis. Results Overall, 551 patients were included and were divided into two groups: those without LVI (LVI−), n = 388 and those with LVI (LVI+), n = 163. LVI+ status was associated with high stage and grade UTUC and lymph node metastasis (P 
ISSN:1464-4096
1464-410X
DOI:10.1111/bju.12116