Postoperative analgesic effects of dexketoprofen, buprenorphine and tramadol in dogs undergoing ovariohysterectomy

The objective of this study was to compare the postoperative analgesic effects of dexketoprofen, tramadol, and buprenorphine in dogs undergoing ovariohysterectomy. Seventy-five adult female dogs were randomly assigned to receive an intravenous injection (IV) of 1mg/kg of dexketoprofen (D), 0.02mg/kg...

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Bibliographic Details
Published in:	Research in veterinary science 2013-08, Vol.95 (1), p.278-282
Main Authors:	Morgaz, J., Navarrete, R., Muñoz-Rascón, P., Domínguez, J.M., Fernández-Sarmiento, J.A., Gómez-Villamandos, R.J., Granados, M.M.
Format:	Article
Language:	eng
Subjects:	adults analgesia Analgesia - veterinary Analgesics Analgesics, Opioid - pharmacology Animals Buprenorphine Buprenorphine - pharmacology Dexketoprofen Dogs Dogs - surgery Female Heart rate Hysterectomy - veterinary Injections, Intravenous - veterinary intravenous injection Ketoprofen - pharmacology Laboratory animals Ovariectomy - veterinary Ovariohysterectomy Pain Pain Measurement - veterinary Pain, Postoperative - drug therapy Pain, Postoperative - prevention & control Pain, Postoperative - veterinary Postoperative period Random Allocation Serotonin spaying Statistics, Nonparametric Surgery Tramadol Tramadol - pharmacology
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Summary:	The objective of this study was to compare the postoperative analgesic effects of dexketoprofen, tramadol, and buprenorphine in dogs undergoing ovariohysterectomy. Seventy-five adult female dogs were randomly assigned to receive an intravenous injection (IV) of 1mg/kg of dexketoprofen (D), 0.02mg/kg of buprenorphine (B) or 2mg/kg of tramadol (T). Pain assessment was performed during 48h after ovariohysterectomy using a dynamic interactive visual analogue scale (DIVAS) and Glasgow composite measure pain scale (CMPS-SF). Rescue analgesia was required in 43%, 21%, and 5% of dogs in the B, T, and D groups, respectively, with significant differences between B and D (p=0.010) groups. The DIVAS and CMPS-SF values of the B group were significantly higher than those of the T and D groups. The most common undesirable effect was dysphoria in dexketoprofen group. Tramadol and dexketoprofen provide superior postoperative analgesia compared with buprenorphine in dogs undergoing ovariohysterectomy.
ISSN:	0034-5288 1532-2661