Prognostic Value of Disseminated Tumor Cells in the Bone Marrow of Patients with Operable Primary Breast Cancer: A Long-term Follow-up Study

Background Detection of disseminated tumor cells (DTC) in primary breast cancer (BC) patients’ bone marrow (BM) seems to be a surrogate marker of tumor spread and an independent prognostic factor for disease-free and overall survival. Methods Here we present the largest single-center cohort of patie...

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Bibliographic Details
Published in:Annals of surgical oncology 2013-06, Vol.20 (6), p.1865-1871
Main Authors: Domschke, Christoph, Diel, Ingo J., Englert, Stefan, Kalteisen, Silvia, Mayer, Luisa, Rom, Joachim, Heil, Joerg, Sohn, Christof, Schuetz, Florian
Format: Article
Language:English
Subjects:
Adult
Bone Marrow - pathology
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Breast Oncology
Disease-Free Survival
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Lymphatic Metastasis
Medicine
Medicine & Public Health
Middle Aged
Mucin-1 - metabolism
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Neoplastic Cells, Circulating - metabolism
Oncology
Proportional Hazards Models
Surgery
Surgical Oncology
Time Factors
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Summary:Background Detection of disseminated tumor cells (DTC) in primary breast cancer (BC) patients’ bone marrow (BM) seems to be a surrogate marker of tumor spread and an independent prognostic factor for disease-free and overall survival. Methods Here we present the largest single-center cohort of patients ( n  = 1378) with the longest observation time (median 82.0 months). Immunocytochemical staining was performed using murine monoclonal antibody 2E11 with the avidin–biotin complex technique. Results At primary surgery, 49 % of patients showed MUC-1 positive cells inside their BM. Patients without BM DTC had significantly more often T1-tumors ( P  = 0.007) with less often affected axillary lymph nodes ( P  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-012-2814-4