Plants from Northeast Mexico with Anti-HSV Activity

Based on chemotaxonomic and ethno-pharmacological criteria, three Mexican plants (Jatropha dioica, Salvia texana and S. ballotaeflora) were studied for in vitro activity against HSV-1 and HSV-2. Hydro-methanolic extracts were initially evaluated for their toxicity to Vero cells. Both Salvia species...

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Bibliographic Details
Published in:Natural product communications 2013-03, Vol.8 (3), p.297-298
Main Authors: Silva-Mares, David, Torres-López, Ernesto, Rivas-Estilla, Ana M, Cordero-Pérez, Paula, Waksman-Minsky, Noemí, Rivas-Galindo, Verónica M
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Herpesvirus 1, Human - drug effects
Herpesvirus 2, Human - drug effects
Humans
Jatropha - chemistry
Mexico
Plant Extracts - chemistry
Plant Extracts - pharmacology
Salvia - chemistry
Vero Cells
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Summary:Based on chemotaxonomic and ethno-pharmacological criteria, three Mexican plants (Jatropha dioica, Salvia texana and S. ballotaeflora) were studied for in vitro activity against HSV-1 and HSV-2. Hydro-methanolic extracts were initially evaluated for their toxicity to Vero cells. Both Salvia species displayed cytotoxicity at the lowest dose (125 μg/mL). The J. dioica extract showed only negligible cytotoxicity (CC50 644 μg/mL). Its anti-HSV activity was evaluated using the plaque reduction assay with HSV-1 and HSV-2 (from clinical isolates) infected Vero cells. The hydro-methanolic extract of J. dioica showed IC50s of 280 and 370 μg/mL against HSV-1 and HSV-2, respectively. The n-hexane liquid-liquid partition of J. dioica extract contained the majority of the active principle(s) with IC50 values of 300 and 270 μg/mL for HSV-1 and HSV-2, respectively. Bioassay-guided isolation led to the known diterpene, riolozatrione.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1300800305