Effect of epicardial adipose tissue on diastolic functions and left atrial dimension in untreated hypertensive patients with normal systolic function

Abstract Background Adipose tissue is the source of many adipokines affecting the cardiovascular system either locally or systemically. Although hypertension is one of the most important factors in diastolic dysfunction (DD), the exact cause of this relationship is unknown. There is no specific stud...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiology 2013-05, Vol.61 (5), p.359-364
Main Authors: Çetin, Mustafa, MD, Kocaman, Sinan Altan, MD, Durakoğlugil, Murtaza Emre, MD, Erdoğan, Turan, MD, Ergül, Elif, MD, Dogan, Sıtkı, MD, Çanga, Aytun, MD
Format: Article
Language:English
Subjects:
Adipose Tissue - physiopathology
Adult
Area Under Curve
Cardiovascular
Cross-Sectional Studies
Diastole - physiology
Diastolic dysfunction
Echocardiography
Epicardial adipose tissue
Female
Heart Atria - physiopathology
Humans
Hypertension
Hypertension - physiopathology
Left atrial dilatation
Male
Middle Aged
Obesity
Obesity - complications
Obesity - physiopathology
Pericardium - physiopathology
Regression Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Adipose tissue is the source of many adipokines affecting the cardiovascular system either locally or systemically. Although hypertension is one of the most important factors in diastolic dysfunction (DD), the exact cause of this relationship is unknown. There is no specific study in the current literature regarding the association of epicardial adipose tissue (EAT) with left ventricular DD in patients with essential hypertension. Methods The present study was cross-sectional and observational, including 127 patients with untreated hypertension who underwent a complete transthoracic echocardiographic examination as well as measurements of EAT and diastolic parameters. Results EAT was significantly correlated with left atrial dimension, DD parameters, and left ventricular (LV) mass as well as age and blood pressure measurements. EAT was also correlated with Framingham risk score ( p < 0.001). Age and EAT were significantly increased in patients with high grades of DD compared to those with low values ( p < 0.001 and p = 0.001, respectively). Linear regression analyses revealed EAT as an independent predictor of all DD parameters. The area under the curve values of EAT were similar to age and higher than those of LV mass and mean BP for both the presence of DD and grade two DD. Conclusion Based on our findings, increased EAT may be associated with diastolic dysfunction and left atrial dilatation due to local or systemic effects in untreated hypertensive patients. This relationship is independent of and stronger than abdominal obesity, implicating the clinical importance of measuring EAT thickness.
ISSN:0914-5087
1876-4738
DOI:10.1016/j.jjcc.2012.12.015