Prostate volume as an independent predictor of prostate cancer in men with PSA of 10-50 ng ml(-1)

Prostate volume (PV) has been shown to be associated with prostate cancer (PCa) detection rates in men with a prostate-specific antigen (PSA) in the 'grey zone' (2.0-10.0 ng ml(-1)). However, the PSA 'grey zone' in Asian men should be higher because the incidence of PCa in Asian...

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Bibliographic Details
Published in:Asian journal of andrology 2013-05, Vol.15 (3), p.409-412
Main Authors: Tang, Ping, Jin, Xiao-Long, Uhlman, Matthew, Lin, Yu-Rong, Deng, Xiang-Rong, Wang, Bin, Xie, Ke-Ji
Format: Article
Language:English
Subjects:
Aged
Asian Continental Ancestry Group
Biopsy
Humans
Male
Multivariate Analysis
Odds Ratio
Organ Size
Predictive Value of Tests
Prostate - pathology
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - pathology
Retrospective Studies
Risk Assessment
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Summary:Prostate volume (PV) has been shown to be associated with prostate cancer (PCa) detection rates in men with a prostate-specific antigen (PSA) in the 'grey zone' (2.0-10.0 ng ml(-1)). However, the PSA 'grey zone' in Asian men should be higher because the incidence of PCa in Asian men is relatively low. Therefore, we evaluated the association between PV and PCa detection rates in men with PSAs measuring 10-50 ng ml(-1). Men who underwent a 13-core prostatic biopsy with PV documentation participated in the study. A multivariate stepwise regression was used to evaluate whether the PV at time of prostate biopsy could predict the risk of PCa. The rates of PCa among men in different PSA ranges, stratified by PV medians (
ISSN:1745-7262
DOI:10.1038/aja.2013.11