Identification of novel HLA-A0201-restricted cytotoxic T lymphocyte epitopes from Zinc Transporter 8

Highlights ► We predicted and identified HLA-A*0201-restricted CTL epitope from ZnT8. ► We utilized it to immunize HLA-A2.1/Kb transgenic (Tg) mice. ► The peptides could elicit specific CTLs in vitro , and induce diabetes in mice. ► The peptides could have therapeutic potential in preventing of T1D....

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Bibliographic Details
Published in:Vaccine 2013-03, Vol.31 (12), p.1610-1615
Main Authors: Li, Shufa, Li, Haiying, Chen, Bing, Lu, Debin, Deng, Wuquan, Jiang, Youzhao, Zhou, Zhongqi, Yang, Zhao
Format: Article
Language:English
Subjects:
Algorithms
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Cytotoxic T lymphocyte
Cytotoxicity
Diabetes
Epitopes
Fundamental and applied biological sciences. Psychology
HLA-A0201
Lymphocytes
Microbiology
Peptides
Rodents
Social change
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Zinc Transporter 8
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Summary:Highlights ► We predicted and identified HLA-A*0201-restricted CTL epitope from ZnT8. ► We utilized it to immunize HLA-A2.1/Kb transgenic (Tg) mice. ► The peptides could elicit specific CTLs in vitro , and induce diabetes in mice. ► The peptides could have therapeutic potential in preventing of T1D.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2012.12.008