Reduced expression of SOCS2 and SOCS6 in hepatocellular carcinoma correlates with aggressive tumor progression and poor prognosis

To investigate the clinical significance of suppressor of cytokine signaling (SOCS)-2 and SOCS6 in human hepatocellular carcinoma (HCC). The expression levels of SOCS2 and SOCS6 mRNA and protein in tumor, para-tumor and normal liver tissues were detected in 106 HCC patients by real-time quantitative...

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Published in:Molecular and cellular biochemistry 2013-06, Vol.378 (1-2), p.99-106
Main Authors: Qiu, Xinyu, Zheng, Jianyong, Guo, Xiaodong, Gao, Xingchun, Liu, Hui, Tu, Yanyang, Zhang, Yongsheng
Format: Article
Language:English
Subjects:
Adult
Aged
Biochemistry
Biomedical and Life Sciences
Blotting, Western
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Cardiology
Cytokines
Development and progression
Disease Progression
Disease-Free Survival
Female
Gene Expression
Hepatoma
Humans
Kaplan-Meier Estimate
Life Sciences
Liver cancer
Liver Neoplasms - metabolism
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Male
Medical Biochemistry
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local - metabolism
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Oncology
Pathology
Prognosis
Proteins
Real-Time Polymerase Chain Reaction
RNA
Suppressor of Cytokine Signaling Proteins - genetics
Suppressor of Cytokine Signaling Proteins - metabolism
Tumors
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Summary:To investigate the clinical significance of suppressor of cytokine signaling (SOCS)-2 and SOCS6 in human hepatocellular carcinoma (HCC). The expression levels of SOCS2 and SOCS6 mRNA and protein in tumor, para-tumor and normal liver tissues were detected in 106 HCC patients by real-time quantitative RT-PCR (qRT-PCR) and Western blot. According to qRT-PCR and western blot analyses, we first found that both the expression levels of SOCS2 and SOCS6 mRNA and protein in HCC were significantly lower than those in para-tumor (both P  
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-013-1599-5