Comparative Analysis of Oncologic Outcomes of Partial Ureterectomy vs Radical Nephroureterectomy in Upper Tract Urothelial Carcinoma

Objective To compare oncologic outcomes in an international cohort of patients who underwent either partial ureterectomy (PU) or radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Methods A subgroup of patients from the UTUC Collaboration with operation classified as PU or...

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Bibliographic Details
Published in:	Urology (Ridgewood, N.J.) N.J.), 2013-05, Vol.81 (5), p.972-978
Main Authors:	Bagrodia, Aditya, Kuehhas, Franklin E, Gayed, Bishoy A, Wood, Christopher G, Raman, Jay D, Kapur, Payal, Derweesh, Ithaar H, Bensalah, Karim, Sagalowsky, Arthur I, Shariat, Shahrokh F, Lotan, Yair, Margulis, Vitaly
Format:	Article
Language:	eng
Subjects:	Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - surgery Female Follow-Up Studies Humans Kaplan-Meier Estimate Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Recurrence, Local Nephrectomy - methods Nephrology. Urinary tract diseases Prognosis Retrospective Studies Tumors Tumors of the urinary system United States - epidemiology Ureter - pathology Ureter - surgery Ureteral Neoplasms - mortality Ureteral Neoplasms - pathology Ureteral Neoplasms - surgery Urinary tract. Prostate gland Urology Urothelium - pathology
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Summary:	Objective To compare oncologic outcomes in an international cohort of patients who underwent either partial ureterectomy (PU) or radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Methods A subgroup of patients from the UTUC Collaboration with operation classified as PU or RNU was used (n = 835). Clinicopathologic outcomes were evaluated. Survival was assessed using the Kaplan-Meier method. Cox regression addressed recurrence-free survival (RFS) and cancer-specific survival (CSS). Results Median age and follow-up were 69 years (range 32-97 years) and 34 months (range 1-246 months), respectively. Relapse occurred in 28.5% of patients (19.6% local, 8.9% systemic). At analysis, 180 patients (21.6%) died of UTUC. Eighty-one patients (9.7%) underwent PU and 754 (90.3%) underwent RNU. High tumor grade (77.3% vs 55.6%, P T1, 41.7% vs 30.9%, P
ISSN:	0090-4295 1527-9995