MRI of carotid atherosclerosis to identify TIA and stroke patients who are at risk of a recurrence

Purpose: To evaluate the potential of carotid plaque MRI to predict transient ischemic attack (TIA) and stroke recurrence in previously symptomatic patients. Materials and Methods: One hundred twenty‐six TIA/stroke patients with ipsilateral 30–69% carotid stenosis underwent multisequence carotid pla...

Full description

Saved in:
Bibliographic Details
Published in:Journal of magnetic resonance imaging 2013-05, Vol.37 (5), p.1189-1194
Main Authors: Kwee, Robert M., van Oostenbrugge, Robert J., Mess, Werner H., Prins, Martin H., van der Geest, Rob J., ter Berg, Johannes W.M., Franke, Cees L., Korten, Arthur G.G.C., Meems, Bé J., van Engelshoven, Jos M.A., Wildberger, Joachim E., Kooi, M. Eline
Format: Article
Language:English
Subjects:
Aged
Carotid Artery Diseases - epidemiology
Carotid Artery Diseases - pathology
carotid atherosclerosis
Comorbidity
Female
Humans
Incidence
Ischemic Attack, Transient - epidemiology
Ischemic Attack, Transient - pathology
Magnetic Resonance Angiography - statistics & numerical data
Magnetic resonance imaging
Male
MRI
Netherlands - epidemiology
plaque
Prognosis
Recurrence
Reproducibility of Results
Risk Assessment
Sensitivity and Specificity
stroke
Stroke - epidemiology
Stroke - pathology
TIA
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: To evaluate the potential of carotid plaque MRI to predict transient ischemic attack (TIA) and stroke recurrence in previously symptomatic patients. Materials and Methods: One hundred twenty‐six TIA/stroke patients with ipsilateral 30–69% carotid stenosis underwent multisequence carotid plaque MRI. The presence of a lipid‐rich necrotic core (LRNC), fibrous cap (FC) status, and intraplaque hemorrhage (IPH) were assessed. Patients were followed to determine the recurrence of ipsilateral TIA and/or stroke within 1 year after inclusion. Results: Thirteen patients suffered from recurrent ipsilateral clinical ischemic events (10 TIAs and 3 strokes). Carotid stenosis grade was not associated with recurrent events (hazard ratio [HR] for 50–69% versus 30–49% stenosis = 1.198; 95% confidence interval [CI], 0.383 to 3.749; P = 0.756). The presence of an LRNC (HR = 3.2001; 95% CI, 1.078 to 9.504; P = 0.036), a thin and/or ruptured FC (HR = 5.756; 95% CI, 1.913 to 17.324; P = 0.002), and IPH (HR = 3.542; 95% CI, 1.058 to 11.856; P = 0.040) were associated with recurrence. Conclusion: The presence of MRI‐depicted LRNC, a thin and/or ruptured FC, and IPH are associated with the recurrence of clinical cerebrovascular ischemic events in TIA and stroke patients with carotid atherosclerosis. J. Magn. Reson. Imaging 2013;37:1189–1194. © 2013 Wiley Periodicals, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.23918