A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer’s disease

Monoamine oxidase (MAO) enzyme inhibition is a crucial target for the management of depression and Alzheimer disease and inhibitors of MAO are the most important drugs for their management. Coumarins are a large family of compounds, of natural and synthetic origin, that exhibit a variety of pharmaco...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2013-05, Vol.21 (9), p.2434-2450
Main Authors: Patil, Pravin O., Bari, Sanjay B., Firke, Sandip D., Deshmukh, Prashant K., Donda, Shailesh T., Patil, Dilip A.
Format: Article
Language:English
Subjects:
Alzheimer disease
Alzheimer Disease - drug therapy
Alzheimer Disease - enzymology
Alzheimer Disease - metabolism
Alzheimer’s disease
amine oxidase (flavin-containing)
Benzopyrones
Coumarin
Coumarins - chemical synthesis
Coumarins - chemistry
Coumarins - pharmacology
Depression
Depression - drug therapy
Depression - enzymology
Depression - metabolism
Drug Design
drugs
enzyme inhibition
Humans
Models, Molecular
Molecular Structure
Monoamine Oxidase - metabolism
Monoamine oxidase inhibitors
Monoamine Oxidase Inhibitors - chemical synthesis
Monoamine Oxidase Inhibitors - chemistry
Monoamine Oxidase Inhibitors - pharmacology
Structure-Activity Relationship
structure-activity relationships
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Summary:Monoamine oxidase (MAO) enzyme inhibition is a crucial target for the management of depression and Alzheimer disease and inhibitors of MAO are the most important drugs for their management. Coumarins are a large family of compounds, of natural and synthetic origin, that exhibit a variety of pharmacological activities, including MAO inhibition. The current review highlights the design and synthetic methods of coumarin derivatives as well as coumarins obtained from plant source as MAO inhibitors for treatment of depression and Alzheimer disease with salient finding related to structure–activity relationship. The aim of present review is to find out natural as well as synthetic coumarins as MAO inhibitors.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2013.02.017