Modulating Roles of Smoking Status and Sex on Oxycodone-Induced Nausea and Drug Liking

Two prominent and important risk factors for nonmedical use of prescription opioids (NMUPO) identified in epidemiological studies are smoking status and sex (i.e., there is a greater likelihood of NMUPO in smokers and in men, relative to nonsmokers and women). Interestingly, nonsmokers and women are...

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Bibliographic Details
Published in:Experimental and clinical psychopharmacology 2013-04, Vol.21 (2), p.103-111
Main Authors: Zacny, James P., Apfelbaum, Sean M., Perkins, Kenneth A.
Format: Article
Language:English
Subjects:
Adult
Affection
Cannabis Use Disorder
Dose-Response Relationship, Drug
Drug Addiction
Epidemiology
Female
Human
Human Sex Differences
Humans
Male
Motivation
Nausea
Nausea - chemically induced
Nicotine
Opiates
Oxycodone
Oxycodone - administration & dosage
Oxycodone - adverse effects
Risk Factors
Sex Factors
Smoking
Tobacco Smoking
Young Adult
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Summary:Two prominent and important risk factors for nonmedical use of prescription opioids (NMUPO) identified in epidemiological studies are smoking status and sex (i.e., there is a greater likelihood of NMUPO in smokers and in men, relative to nonsmokers and women). Interestingly, nonsmokers and women are at greater risk for the aversive effects of postoperative nausea and vomiting. We have conducted six studies examining the subjective effects of oral oxycodone (0, 10, 20 mg) in samples that included both men and women and nonsmokers and light smokers (fewer than six cigarettes per day). Four groups were comprised of 115 volunteers: male smokers (n = 20), male nonsmokers (n = 38), female smokers (n = 15), and female nonsmokers (n = 42). We hypothesized that there would be an additive effect between smoking status and sex such that male smokers would experience less nausea and disliking, and greater overall liking, and that female nonsmokers would respond in the opposite fashion. As predicted, nausea and disliking ratings were lowest, and overall liking ratings the highest, in male smokers after oxycodone administration, whereas nausea and disliking ratings were highest, and overall liking ratings the lowest, in female nonsmokers. Thus, our hypotheses were generally supported, and suggest a possible biobehavioral mechanism for the epidemiological links between smoking status and sex and increased risk of NMUPO.
ISSN:1064-1297
1936-2293
DOI:10.1037/a0031706