Dysphagia due to isoniazid therapy for tuberculosis in a patient with Lewy body dementia

Abstract Dementia with Lewy bodies (DLB) potentially causes dysphagia; however, the features and underlying mechanism causing dysphagia have still not been clarified. We are the first to report a case of dysphagia resulting from isoniazid therapy for tuberculosis in a DLB patient. A 74-year-old woma...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2013-06, Vol.40 (3), p.327-329
Main Authors: Ohki, Masafumi, Tayama, Niro
Format: Article
Language:English
Subjects:
Aged
Antitubercular Agents - administration & dosage
Antitubercular Agents - adverse effects
Deglutition Disorders - chemically induced
Deglutition Disorders - drug therapy
Dopamine Agents - therapeutic use
Drug Interactions
Dysphagia
Endoscopy
Female
Fluoroscopy
Humans
Isoniazid
Isoniazid - administration & dosage
Isoniazid - adverse effects
Levodopa
Levodopa - therapeutic use
Lewy Body Disease - complications
Otolaryngology
Parkinsonism
Tuberculosis
Tuberculosis, Pleural - drug therapy
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Summary:Abstract Dementia with Lewy bodies (DLB) potentially causes dysphagia; however, the features and underlying mechanism causing dysphagia have still not been clarified. We are the first to report a case of dysphagia resulting from isoniazid therapy for tuberculosis in a DLB patient. A 74-year-old woman with DLB developed dysphagia during treatment for tuberculous pleurisy. Oral videoendoscopic and videofluorographic swallowing examinations showed oropharyngeal dysphagia. The increased administration of levodopa successfully ameliorated dysphagia. Therefore, dysphagia was ascribed to diminished levodopa efficacy due to interaction with isoniazid. Thus, DLB patients receiving anti-tuberculous therapy should be closely examined for potential changes in swallowing and Parkinsonism.
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2012.02.005