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Texture analysis of magnetic resonance images of patients with juvenile myoclonic epilepsy
Abstract Background/purpose Juvenile myoclonic epilepsy (JME) is the most frequent subsyndrome of the idiopathic generalized epilepsies, and experimental investigations support that the thalamus is a key structure in the mechanisms of JME. Texture analysis (TA) is an image processing technique which...
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Published in: | Epilepsy & behavior 2013-04, Vol.27 (1), p.22-28 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Abstract Background/purpose Juvenile myoclonic epilepsy (JME) is the most frequent subsyndrome of the idiopathic generalized epilepsies, and experimental investigations support that the thalamus is a key structure in the mechanisms of JME. Texture analysis (TA) is an image processing technique which can be used to characterize images such as MRI. Objective The goal of this work was to investigate the thalamus of patients with JME using TA, a quantitative neuroimaging technique. Methods Patients and controls were submitted to MRI investigation. Images were acquired in a 2-Tesla scanner. The T1 volumetric sequence was used for thalamic segmentation and extraction of texture parameters. Twenty-four patients with a diagnosis of JME and 20 healthy volunteers were investigated. Results Texture analysis revealed differences between the right thalamus of patients and controls. Conclusions The present investigation supports the participation of the thalamus in the disease mechanisms of JME. Texture analysis may be a useful tool in the quantitative neuroimaging investigation of the epilepsies and can be important to understand JME. |
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ISSN: | 1525-5050 1525-5069 |
DOI: | 10.1016/j.yebeh.2012.12.009 |