Relative oral bioavailability of 3-MCPD from 3-MCPD fatty acid esters in rats

In order to quantify the relative oral bioavailability of 3-chloropropane-1,2-diol (3-MCPD) from 3-MCPD fatty acid diesters in vivo, 1,2-dipalmitoyl-3-chloropropane-1,2-diol (3-MCPD diester) and 3-MCPD were orally applied to rats in equimolar doses. In both cases, the time courses of 3-MCPD concentr...

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Bibliographic Details
Published in:Archives of toxicology 2013-04, Vol.87 (4), p.649-659
Main Authors: Abraham, Klaus, Appel, Klaus E., Berger-Preiss, Edith, Apel, Elisabeth, Gerling, Susanne, Mielke, Hans, Creutzenberg, Otto, Lampen, Alfonso
Format: Article
Language:English
Subjects:
Administration, Oral
alpha-Chlorohydrin
Animals
Area Under Curve
Bioavailability
Biological Availability
Biomedical and Life Sciences
Biomedicine
Carcinogens
Carcinogens - chemistry
Carcinogens - pharmacokinetics
Environmental Health
Esters - chemistry
Fatty acids
Fatty Acids - chemistry
Food Contamination - analysis
Gastrointestinal Contents - chemistry
Glycerol - analogs & derivatives
Glycerol - chemistry
Glycerol - pharmacokinetics
Health risk assessment
Hydrolysis
Male
Occupational Medicine/Industrial Medicine
Pharmacology/Toxicology
Rats
Rats, Wistar
Risk Assessment
Rodents
Toxicokinetics and Metabolism
Toxicology
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Summary:In order to quantify the relative oral bioavailability of 3-chloropropane-1,2-diol (3-MCPD) from 3-MCPD fatty acid diesters in vivo, 1,2-dipalmitoyl-3-chloropropane-1,2-diol (3-MCPD diester) and 3-MCPD were orally applied to rats in equimolar doses. In both cases, the time courses of 3-MCPD concentrations were measured in blood, various organs, tissues and intestinal luminal contents. The results show that 3-MCPD is released by enzymatic hydrolysis from the 3-MCPD diester in the gastrointestinal tract and distributed to blood, organs and tissues. Based on the measurements in blood, the areas under the curve (AUC) for 3-MCPD were calculated. By comparing both AUC, the relative amount of 3-MCPD bioavailable from the 3-MCPD diester was calculated to be 86 % on average of the amount bioavailable following administration of 3-MCPD. In view of limited experimental data, it is justified for the purpose of risk assessment to assume complete hydrolysis of the diesters in the gastro-intestinal tract. Therefore, assessment of the extent of exposure to 3-MCPD released from its fatty acid esters should be performed in the same way as exposure to the same molar quantity of 3-MCPD.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-012-0970-8