Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children

Background We previously showed that impulse oscillometry (IOS) indices of peripheral airway function are associated with asthma control in children. However, little data exist on whether dysfunction in the peripheral airways can predict loss of asthma control. Objective We sought to determine the u...

Full description

Saved in:
Bibliographic Details
Published in:Journal of allergy and clinical immunology 2013-03, Vol.131 (3), p.718-723
Main Authors: Shi, Yixin, MS, Aledia, Anna S., BS, Galant, Stanley P., MD, George, Steven C., MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Age
Airway Resistance
Allergy and Immunology
Asthma
Asthma - diagnosis
Asthma - physiopathology
Biological and medical sciences
Child
Children
Chronic obstructive pulmonary disease, asthma
Colleges & universities
Data processing
Female
Frequency dependence
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunopathology
Impulse oscillometry
longitudinal
Lung - physiopathology
lung function
Male
Medical sciences
Nitric oxide
Oscillometry
pediatric
Pneumology
Prevention programs
Reporting requirements
Respiratory system
Respiratory tract
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Spirometry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background We previously showed that impulse oscillometry (IOS) indices of peripheral airway function are associated with asthma control in children. However, little data exist on whether dysfunction in the peripheral airways can predict loss of asthma control. Objective We sought to determine the utility of peripheral airway impairment, as measured by IOS, in predicting loss of asthma control in children. Methods Fifty-four children (age, 7-17 years) with controlled asthma were enrolled in the study. Spirometric and IOS indices of airway function were obtained at baseline and at a follow-up visit 8 to 12 weeks later. Physicians who were blinded to the IOS measurements assessed asthma control (National Asthma Education and Prevention Program guidelines) on both visits and prescribed no medication change between visits. Results Thirty-eight (70%) patients maintained asthma control between 2 visits (group C-C), and 16 patients had asthma that became uncontrolled on the follow-up visit (group C-UC). There was no difference in baseline spirometric results between the C-C and C-UC groups, except for FEV1 /forced vital capacity ratio (86% vs 82%, respectively; P  
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2012.09.022