Experimental Study of the Effects of Dietressa, a New Weight-Reducing Drug

The capacity of a new drug containing ultra-low doses of antibodies to cannabinoid receptor type 1 (Dietressa) to reduce body weight gain in mice on a high-calorie diet was evaluated, possible mechanisms of drug action were analyzed, and its safety (abuse potential in the reaction of self-stimulatio...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012, Vol.152 (3), p.321-324
Main Authors: Kheyfets, I. A., Bugaeva, L. I., Vorob’eva, T. M., Dugina, J. L., Lebedeva, S. A., Petrov, V. I., Sergeeva, S. A., Epstein, O. I.
Format: Article
Language:English
Subjects:
Animals
Anti-Obesity Agents - pharmacology
Antibodies
Antibodies - pharmacology
Biomedical and Life Sciences
Biomedicine
Body weight
Body weight gain
Cannabinoid receptors
Cell Biology
Cyclobutanes - metabolism
Cyclobutanes - pharmacology
Diabetes therapy
Diets
Drug abuse
Drug Evaluation, Preclinical
Drug therapy
Drugs
Eating - drug effects
Eating - physiology
Internal Medicine
Laboratory Medicine
Male
Mice
Obesity
Obesity - prevention & control
Pathology
Pharmacology and Toxicology
Receptor, Cannabinoid, CB1 - immunology
Self-stimulation
sibutramine
Weight Loss - drug effects
Weight reducing preparations
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Summary:The capacity of a new drug containing ultra-low doses of antibodies to cannabinoid receptor type 1 (Dietressa) to reduce body weight gain in mice on a high-calorie diet was evaluated, possible mechanisms of drug action were analyzed, and its safety (abuse potential in the reaction of self-stimulation) was evaluated. Dietressa was not inferior to sibutramine in reducing body weight gain in mice and exhibited no abuse potential.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1518-x