Synthesis, characterization, and micellization of cholesteryl-modified amphiphilic poly(L-lactide)-block-poly(glycidyl methacrylate) as a nanocarrier for hydrophobic drugs

The biodegradable polymer cholesteryl-( L -lactic acid) 50 , CLA 50 , was synthesized via ring-opening polymerization of L -lactide in the presence of cholesterol as an initiator and a catalytic amount of Sn(Oct) 2 . The resulting monohydroxyl-terminated CLA 50 was subsequently converted to a bromin...

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Bibliographic Details
Published in:	Journal of polymer research 2013-02, Vol.20 (2), p.1-9, Article 59
Main Authors:	Bagheri, Massoumeh, Motirasoul, Forough
Format:	Article
Language:	eng
Subjects:	Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Copolymers Drugs Industrial Chemistry/Chemical Engineering Micelles Nanostructure Naproxen Original Paper Polymer Sciences Polymerization Self assembly Transmission electron microscopy
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Summary:	The biodegradable polymer cholesteryl-( L -lactic acid) 50 , CLA 50 , was synthesized via ring-opening polymerization of L -lactide in the presence of cholesterol as an initiator and a catalytic amount of Sn(Oct) 2 . The resulting monohydroxyl-terminated CLA 50 was subsequently converted to a bromine-ended macroinitiator (CLA 50 –Br) by esterification with 2-bromisobutyryl bromide. The amphiphilic diblock copolymer CLA 50 -b-PGMA was then synthesized via atom transfer radical polymerization of glycidyl methacrylate (GMA). The resulting polymers were characterized by FTIR, 1 H NMR, GPC, and DSC. Polymeric micelles were prepared by the co-solvent evaporation method. The aqueous self-assembly of the copolymer CLA 50 -b-PGMA was investigated by TEM and DLS. Using naproxen as a hydrophobic model drug, drug-loaded micelles were prepared. TEM images of naproxen-loaded micelles of the copolymer (which exhibited a loading efficiency of 76.5 % and a loading capacity of 15.3 %) showed that the micelles were spherical and had diameters of 29–40 nm. An in vitro release study of naproxen was performed using the dialysis method in a phosphate-buffered solution at 37 °C. According to the results obtained in this work, these polymeric micelles could be tailored (by modifying the copolymer composition and molecular weight of blocks) to act as effective drug carriers that facilitate the release of various drugs.
ISSN:	1022-9760 1572-8935