Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis

Abstract In allergen challenged animal models, eosinophils localize to airway nerves leading to vagally-mediated hyperreactivity. We hypothesized that in allergic rhinitis eosinophils recruited to nasal nerves resulted in neural hyperreactivity. Patients with persistent allergic rhinitis (n = 12), s...

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Bibliographic Details
Published in:Clinical immunology (Orlando, Fla.) Fla.), 2013-04, Vol.147 (1), p.50-57
Main Authors: Thornton, Margaret A, Akasheh, Nadim, Walsh, Marie-Therese, Moloney, Michael, Sheahan, Patrick O, Smyth, Claire M, Walsh, Rory McConn, Morgan, Ross M, Curran, David R, Walsh, Michael T, Gleich, Gerald J, Costello, Richard W
Format: Article
Language:English
Subjects:
Allergens - immunology
Allergic rhinitis
Allergy and Immunology
Chemokine CCL26
Chemokines, CC - immunology
Chemokines, CC - metabolism
Eosinophils
Eosinophils - immunology
Eosinophils - metabolism
Humans
Immunohistochemistry
Nasal Mucosa - immunology
Nasal Mucosa - innervation
Nasal Mucosa - metabolism
Nasal Provocation Tests
Nervous System - immunology
Nervous System - metabolism
Neural hyperreactivity
Rhinitis, Allergic
Rhinitis, Allergic, Perennial - immunology
Rhinitis, Allergic, Perennial - metabolism
Rhinitis, Allergic, Seasonal - immunology
Rhinitis, Allergic, Seasonal - metabolism
Vascular Cell Adhesion Molecule-1 - immunology
Vascular Cell Adhesion Molecule-1 - metabolism
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Summary:Abstract In allergen challenged animal models, eosinophils localize to airway nerves leading to vagally-mediated hyperreactivity. We hypothesized that in allergic rhinitis eosinophils recruited to nasal nerves resulted in neural hyperreactivity. Patients with persistent allergic rhinitis (n = 12), seasonal allergic rhinitis (n = 7) and controls (n = 10) were studied. Inferior nasal turbinate biopsies were obtained before, 8 and 48 h after allergen challenge. Eight hours after allergen challenge eosinophils localized to nerves in both rhinitis groups; this was sustained through 48 h. Bradykinin challenge, with secretion collection on the contralateral side, was performed to demonstrate nasal nerve reflexes. Twenty four hours after allergen challenge, bradykinin induced a significant increase in secretions, indicating nasal hyperreactivity. Histological studies showed that nasal nerves expressed both vascular cell adhesion molecule-1 (VCAM-1) and chemokine (C-C motif) ligand 26 (CCL-26). Hence, after allergen challenge eosinophils are recruited and retained at nerves and so may be a mechanism for neural hyperreactivity.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2013.02.008