Protective Effect of Lactoferrin on Cisplatin-Induced Nephrotoxicity in Rats

Although cisplatin (cis-diamminedichloroplatinum II) is one of the most effective chemotherapeutic agents, its clinical use is limited because of its strong side effects on the kidneys. The aim of this study was to investigate the renoprotective effect of bovine lactoferrin (bLf) in cisplatin-induce...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2013, Vol.75(2), pp.159-164
Main Authors: KIMOTO, Yumi, NISHINOHARA, Masaaki, SUGIYAMA, Akihiko, HARUNA, Akihiro, TAKEUCHI, Takashi
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - toxicity
cisplatin
Cisplatin - toxicity
diuresis
Diuresis - drug effects
Dose-Response Relationship, Drug
Kidney Diseases - chemically induced
Kidney Diseases - prevention & control
lactoferrin
Lactoferrin - administration & dosage
Lactoferrin - pharmacology
nephrotoxicity
Rats
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Summary:Although cisplatin (cis-diamminedichloroplatinum II) is one of the most effective chemotherapeutic agents, its clinical use is limited because of its strong side effects on the kidneys. The aim of this study was to investigate the renoprotective effect of bovine lactoferrin (bLf) in cisplatin-induced renal failure in rats. To assess the renoprotective effect of bLf, oral bLf (300 mg/kg) was administered from the day before to the fifth day after cisplatin (7 mg/kg, i.p.) injection. Daily administration of bLf histologically reduced renal tubular injury induced by cisplatin and suppressed the deterioration of renal function. Accumulated platinum content in the kidney was significantly decreased by the daily administration of bLf. Moreover, the administration of intravenous bLf caused a significant increase in urine volume in a dose-dependent manner. These results suggest that pretreatment with bLf produces a protective effect against cisplatin-induced nephrotoxicity. This protective effect of bLf involves the reduction of accumulated cisplatin in the kidney.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.12-0154