Anti-inflammatory, Antioxidant and Cytotoxicity Activities of Methanolic Extract and Prenylated Flavanones Isolated from Leaves of Eysehardtia platycarpa

From the methanolic extract of Eysenhardtia platycarpa (leaves), were isolated the prenylated flavanones: 5,7-dihydroxy-6-methyl-8-prenylflavanone (1), 5,7-dihydroxy-6-methyl-8-prenyl-4′-methoxy-flavanone (2), 5,7-dihydroxy-6-prenylflavanone (3), 5-dihydroxy-7-methoxy-6-prenylflavanone (4), 5,7-dihy...

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Bibliographic Details
Published in:Natural product communications 2013-02, Vol.8 (2), p.177-180
Main Authors: Domínguez-Villegas, Valeri, Domínguez-Villegas, Vanessa, García, María Luisa, Calpena, Ana, Clares-Naveros, Beatriz, Garduño-Ramírez, María Luisa
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Antioxidants - pharmacology
Artemia
Fabaceae - chemistry
Flavanones - isolation & purification
Flavanones - pharmacology
Flavanones - toxicity
Male
Mice
Plant Extracts - pharmacology
Plant Leaves - chemistry
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Summary:From the methanolic extract of Eysenhardtia platycarpa (leaves), were isolated the prenylated flavanones: 5,7-dihydroxy-6-methyl-8-prenylflavanone (1), 5,7-dihydroxy-6-methyl-8-prenyl-4′-methoxy-flavanone (2), 5,7-dihydroxy-6-prenylflavanone (3), 5-dihydroxy-7-methoxy-6-prenylflavanone (4), 5,7-dihydroxy-8-prenyl-4′-methoxy-flavanone (5). Methanolic extract of E. platycarpa (leaves) and flavanones (5), (2) and (3) showed anti-inflammatory activity according to tested quantities. In addition, flavanone (5) revealed the best percentage reduction of free radical DPPH. Finally, after cytotoxic activity study, the methanolic extract from E. platycarpa leaves and flavanone (4) exhibited promising cytotoxic activity on brine shrimp.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1300800211