Hepatocyte growth factor and interferon-γ inducible protein-10 are related to visceral adiposity

Background Increased production of chemokines by adipose tissue and defective adipose tissue oxygenation as a result of obesity may induce leucocyte infiltration and subsequent systemic inflammation. Objectives 1‐To determine the relation between the amount of visceral and subcutaneous adipose tissu...

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Published in:European journal of clinical investigation 2013-04, Vol.43 (4), p.369-378
Main Authors: Faber, Daniël R., van der Graaf, Yolanda, Westerink, Jan, Kanhai, Danny A., Monajemi, Houshang, Visseren, Frank L. J.
Format: Article
Language:English
Subjects:
Adipose tissue
Aged
Body Mass Index
Chemokine CXCL10 - metabolism
Female
Hepatocyte Growth Factor - metabolism
HGF
Humans
inflammation
Inflammation - complications
Inflammation - metabolism
Intra-Abdominal Fat - metabolism
IP-10
Male
Metabolic Syndrome - complications
Metabolic Syndrome - metabolism
Middle Aged
obesity
Regression Analysis
Subcutaneous Fat - metabolism
vascular disease
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Summary:Background Increased production of chemokines by adipose tissue and defective adipose tissue oxygenation as a result of obesity may induce leucocyte infiltration and subsequent systemic inflammation. Objectives 1‐To determine the relation between the amount of visceral and subcutaneous adipose tissue and the chemokine interferon‐γ‐inducible protein 10 (IP‐10) and angiogenic factor hepatocyte growth factor (HGF). 2‐To determine the relation between the metabolic syndrome and IP‐10 as well as HGF. Methods Patients originated from the Secondary Manifestations of ARTerial disease (SMART) cohort. In this study, a cohort of 1251 patients with manifest vascular disease was included. Subcutaneous and visceral adipose tissue thickness (SAT and VAT respectively) were measured ultrasonographically. IP‐10 and HGF concentrations were measured with Luminex multiplex immuno assay in addition to fasting metabolic parameters. Linear regression analyses with adjustments for age, gender, smoking, estimated glomerular filtration rate, type 2 diabetes mellitus and medication use were applied to quantify the relations between adiposity or metabolic syndrome and IP‐10 and HGF concentrations. Results VAT was significantly associated with (log)IP‐10 and (log)HGF, reflected by significant higher β‐values in VAT quartile 4 compared with VAT quartile 1 (reference): β0.155 (95%CI:0.073–0.237) for IP‐10 and β0.147 (95%CI:0.076–0.218) for HGF. Per standard deviation increase in VAT, (log)IP‐10 levels increased with 0.057 pg/mL (95%CI:0.027–0.087) and (log)HGF increased with 0.051 pg/mL (95%CI:0.025–0.077). Effect estimates were not affected by including body mass index(BMI) in the model. In contrast, SAT was not associated with IP‐10 and HGF. Furthermore, the presence of the metabolic syndrome was associated with IP‐10 and HGF. Conclusions Visceral adipose tissue but not subcutaneous adipose tissue is significantly associated with circulating levels of IP‐10 and HGF, irrespective of BMI.
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.12054