Nebivolol treatment increases splanchnic blood flow and portal pressure in cirrhotic rats via modulation of nitric oxide signalling

Background We evaluated the effects of nebivolol, a third generation beta‐blocker capable of increasing NO‐bioavailability on portal pressure, and on splachnic and systemic haemodynamics in a cirrhotic portal hypertensive rat model. Methods Male Sprague–Dawley rats underwent sham operation (SO) or b...

Full description

Saved in:
Bibliographic Details
Published in:Liver international 2013-04, Vol.33 (4), p.561-568
Main Authors: Reiberger, Thomas, Payer, Berit Anna, Schwabl, Philipp, Hayden, Hubert, Horvatits, Thomas, Jäger, Bernhard, Hummel, Thomas, Mitterhauser, Markus, Trauner, Michael, Fuhrmann, Valentin, Angermayr, Bernhard, Peck-Radosavljevic, Markus
Format: Article
Language:English
Subjects:
Administration, Oral
Adrenergic beta-Antagonists - administration & dosage
Adrenergic beta-Antagonists - toxicity
animal study
Animals
Benzopyrans - administration & dosage
Benzopyrans - toxicity
Blood Flow Velocity - drug effects
Collateral Circulation - drug effects
Common Bile Duct - surgery
Dose-Response Relationship, Drug
Ethanolamines - administration & dosage
Ethanolamines - toxicity
Glutathione - metabolism
Heart Rate - drug effects
Hypertension, Portal - etiology
Hypertension, Portal - metabolism
Hypertension, Portal - physiopathology
Ligation
Liver - blood supply
Liver - drug effects
Liver - metabolism
Liver Circulation - drug effects
Liver Cirrhosis, Experimental - complications
Liver Cirrhosis, Experimental - drug therapy
Liver Cirrhosis, Experimental - metabolism
Liver Cirrhosis, Experimental - physiopathology
Male
Mesenteric Artery, Superior - drug effects
Mesenteric Artery, Superior - metabolism
Mesenteric Artery, Superior - physiopathology
Nebivolol
Nitric Oxide - metabolism
Oxidation-Reduction
portal hypertension
Portal Pressure - drug effects
Rats
Rats, Sprague-Dawley
Signal Transduction - drug effects
Splanchnic Circulation - drug effects
Up-Regulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background We evaluated the effects of nebivolol, a third generation beta‐blocker capable of increasing NO‐bioavailability on portal pressure, and on splachnic and systemic haemodynamics in a cirrhotic portal hypertensive rat model. Methods Male Sprague–Dawley rats underwent sham operation (SO) or bile duct ligation (BDL). When cirrhosis was fully developed, the animals were orally treated with low‐dose (5 mg/kg) or high‐dose (10 mg/kg) nebivolol (NEBI) or vehicle (VEH) for 7 days. Heart rate (HR), mean arterial pressure (MAP), portal pressure (PP) and superior mesenteric artery blood flow (SMABF) were measured. Portosystemic collateral blood flow (PSCBF) was quantified using radioactive microspheres. Hepatic and splanchnic NOx levels and GSH/GSSG ratios (RedOx state) were determined using commercially available kits. Results BDL‐VEH rats showed increased HR, PP and PSCBF, whereas MAP was decreased compared to SO‐VEH rats. Nebivolol significantly reduced HR both in SO (P 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.12101