Catechins and osteoporosis

Cortical bone is the hard outer shell of bones and the middle of long bones. Because osteoblasts and osteoclasts inhabit the surface of bones, trabecular bone is more active, thus it is more subject to bone turnover and remodeling. HO-1 participates in the MSC differentiation process, shifting the b...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2013-04, Vol.29 (4), p.697-699
Main Author: Das, Undurti N., M.D., F.A.M.S., F.R.S.C
Format: Article
Language:English
Subjects:
Animals
Antioxidants - therapeutic use
Bone and Bones - immunology
Bone and Bones - metabolism
Bone density
Bones
Catechin - therapeutic use
Dietary Supplements
Estrogens
Estrogens - metabolism
Female
Free radicals
Gastroenterology and Hepatology
Gene expression
Humans
Male
Mens health
Osteoporosis
Osteoporosis - diet therapy
Osteoporosis - immunology
Osteoporosis - metabolism
Osteoporosis - prevention & control
Osteoporosis, Postmenopausal - diet therapy
Osteoporosis, Postmenopausal - immunology
Osteoporosis, Postmenopausal - metabolism
Osteoporosis, Postmenopausal - prevention & control
Oxidative stress
Phytoestrogens - therapeutic use
Womens health
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Summary:Cortical bone is the hard outer shell of bones and the middle of long bones. Because osteoblasts and osteoclasts inhabit the surface of bones, trabecular bone is more active, thus it is more subject to bone turnover and remodeling. HO-1 participates in the MSC differentiation process, shifting the balance of MSC differentiation in favor of the osteoblast lineage by decreasing PPAR-γ and increasing osteogenic markers such as alkaline phosphatase and BMP-2. [...]HO-1 reduces oxidative stress, increases osteoblast differentiation and thus, increases bone formation and prevents osteoporosis [11]. Because LXA4 induces the production and release of eNO [25-27], this implies that estrogen-induced LXA4 synthesis prevents osteoporosis by enhancing eNO generation.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2012.11.002