The TRIMCyp genotype in four species of macaques in China

The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression...

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Bibliographic Details
Published in:Immunogenetics (New York) 2013-03, Vol.65 (3), p.185-193
Main Authors: Yu, Chang-Qing, Na, Lei, Lv, Xiao-Ling, Liu, Jian-Dong, Liu, Xiao-Ming, Ji, Fang, Zheng, Yong-Hui, Du, Hong-Li, Kong, Xian-Gang, Zhou, Jian-Hua
Format: Article
Language:English
Subjects:
Allergology
Alternative splicing
Animal Distribution
Animal models
Animals
Base Sequence
Biomedical and Life Sciences
Biomedicine
Carrier Proteins - genetics
Cell Biology
China
Data processing
Disease Resistance - genetics
Frameshift Mutation
Fusion protein
Gene Function
genomics
Genotype
Genotype & phenotype
HIV Infections - genetics
HIV-1
Human Genetics
Human immunodeficiency virus 1
Immunology
Infection
Infections
Macaca - genetics
Macaca fascicularis
Macaca fascicularis - genetics
Macaca mulatta
Macaca mulatta - genetics
Macaca nemestrina
Macaca nemestrina - genetics
Macaca thibetana
Mitochondrial DNA
Molecular Sequence Data
Monkeys & apes
Mutant Chimeric Proteins - genetics
Original Paper
Polymorphism, Genetic
Protein Isoforms - genetics
Proteins
Proteins - genetics
Pseudogenes
Replication
Retroelements - genetics
Retrotransposition
Species Specificity
Transcription
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Summary:The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression status of TRIMCyp in four species of macaques originating from China and its borderlands: pigtail macaques ( Macaca nemestrina ), rhesus macaques ( Macaca mulatta ), long-tailed macaques ( Macaca fascicularis ), and Tibetan macaques ( Macaca thibetana ). The results revealed that the frequencies of the TRIMCyp genotype were significantly different among different species and even within different populations of the same species. Interestingly, the TRIMCyp genotype was more prevalent among macaques originating from Yunnan and surrounding regions than those from other regions of China. Importantly, TRIMCyp individuals were first identified in Chinese M . mulatta originating from Yunnan, although multiple earlier studies failed to find CypA retrotransposition in this subspecies. Furthermore, TRIMe7-CypA, one of the splicing isoforms of the TRIMCyp transcript was expressed in M . nemestrina and M . mulatta but not M . fascicularis . The intra- and interspecies polymorphisms in the deduced TRIMCyp amino acid sequences of these macaques were also analyzed. Taken together, the data in this study provide important information about the genomic background of TRIMCyp among major species of Chinese macaques.
ISSN:0093-7711
1432-1211
DOI:10.1007/s00251-012-0670-9