Concentration of vascular endothelial growth factor in patients with acute coronary syndrome

► Human VEGF concentration in patients with acute coronary syndrome (STEMI, NSTEMI). ► High level of neutrophils increased OR of high serum hVEGF. ► Increased level of triglycerides decreased OR of high serum hVEGF concentration.. ► Serum VEGF can serve as surrogate marker of myocardial injury. Vasc...

Full description

Saved in:
Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2013-02, Vol.61 (2), p.664-669
Main Authors: Konopka, Anna, Janas, Jadwiga, Piotrowski, Walerian, Stępińska, Janina
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Coronary Syndrome - blood
Biomarkers
blood serum
coronary vessels
Cytokines
Female
Humans
Injuries
Ischemia
Male
Middle Aged
neutrophils
NSTEMI
Odds Ratio
patients
Risk Factors
STEMI
triacylglycerols
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
vascular endothelial growth factors
VEGF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:► Human VEGF concentration in patients with acute coronary syndrome (STEMI, NSTEMI). ► High level of neutrophils increased OR of high serum hVEGF. ► Increased level of triglycerides decreased OR of high serum hVEGF concentration.. ► Serum VEGF can serve as surrogate marker of myocardial injury. Vascular endothelial growth factor (VEGF) is a regulator of vascular formation in physiological and pathological conditions. The aim of our study was to evaluate the value of VEGF as a surrogate marker of myocardial injury in acute ischemic conditions. In 104 consecutive patients with acute coronary syndrome (ACS) with and without ST segment elevation (STEMI and NSTEMI) the plasma and serum human VEGF (hVEGF) concentration was measured two times i.e. immediately after admission due to ACS and 24h later. According to ECG findings and coronary angiography results, patients were divided into three groups. Group A represented major myocardial injury due to ST-segment elevation in precordial leads and/or in I and aVL leads and with left anterior descending (LAD) artery responsible for STEMI symptoms or additionally with significant atherosclerotic lesions (lumen vessel narrowed>50%) in other than LAD coronary arteries. Group B (medium myocardial injury) consisted of patients with ST-segment elevation in II, III and aVF leads and/or ST-segment depression in V2-V3 leads with one-vessel disease and the culprit artery was not LAD. Group C included patients with changes in ECG other than ST-segment elevation independently of the site of atherosclerotic lesions in coronary arteries. In all 104 patients with ACS the highest values of serum hVEGF were observed in second measurement (357.9±346 pg/ml, p
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2012.12.001