Population-based and family-based studies on the protein tyrosine phosphatase non-receptor 22 gene polymorphism and type 1 diabetes: A meta-analysis

Studies investigating the association between PTPN22 gene C1858T polymorphism and type 1 diabetes (T1D) susceptibility among Caucasian population have reported conflicting results. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the relationship...

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Bibliographic Details
Published in:Gene 2013-04, Vol.517 (2), p.191-196
Main Authors: Wang, Xiao-Feng, Chen, Zi-Xian, Shao, Yun-Chao, Ma, Yu-Shui, Zhang, Feng, Zhang, Liang, Fu, Da, Xia, Qing
Format: Article
Language:English
Subjects:
Case-Control Studies
Diabetes Mellitus, Type 1 - genetics
European Continental Ancestry Group - genetics
Female
Genetic Predisposition to Disease
Genetics, Population
Humans
Male
Meta-analysis
Polymorphism
Polymorphism, Genetic
Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics
PTPN22
TDT
Type 1 diabetes
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Summary:Studies investigating the association between PTPN22 gene C1858T polymorphism and type 1 diabetes (T1D) susceptibility among Caucasian population have reported conflicting results. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the relationship between the PTPN22 C1858T polymorphism and T1D. Databases including PubMed, Web of Science, and EMBASE were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. In total, 33 population-based studies with 22, 485 cases and 35, 292 controls, 9 family-based studies involving 7276 families were included. Under the random-effects model, the per-allele overall OR of the C1858T polymorphism for T1D was 1.89 (95% CI: 1.76–2.02, P
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2012.12.076