Enhanced Oral Bioavailability of Astaxanthin with Droplet Size Reduction

Astaxanthin is a natural xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influ...

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Bibliographic Details
Published in:Food Science and Technology Research 2012, Vol.18(4), pp.549-554
Main Authors: AFFANDI, M.M.R. MEOR MOHD, JULIANTO, T., MAJEED, A.B.A.
Format: Article
Language:English
Subjects:
astaxanthin
bioavailability
droplet size reduction
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Summary:Astaxanthin is a natural xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influence of emulsion droplet size on astaxanthin bioavailability is yet to be studied. This study was performed to investigate the effects of emulsion droplet size reduction on the bioavailability of astaxanthin emulsion through oral administration. In vivo study was carried out to evaluate the rate and extent of absorption of macro and nanosized emulsion an oil solution formulation. The nanosized emulsion shows increased Cmax and AUC0-∞ and decreased Tmax values with a reduction of the emulsion globule size. The AUC0-∞ of nanosized compared to macrosized emulsion and oil solution was increased by 110% − 140% and 140% − 200% respectively.
ISSN:1344-6606
1881-3984
DOI:10.3136/fstr.18.549