Meningococcal Quadrivalent (Serogroups A, C, W135 and Y) Tetanus Toxoid Conjugate Vaccine (Nimenrix™)

Nimenrix™ (MenACWY-TT) is a quadrivalent meningococcal conjugate vaccine, comprising the polysaccharide serogroups A, C, W135 and Y, and tetanus toxoid (TT) as carrier protein. It is the first quadrivalent vaccine (administered as a single dose) to be approved in Europe for active immunization of in...

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Bibliographic Details
Published in:Drugs (New York, N.Y.) N.Y.), 2012-12, Vol.72 (18), p.2407-2430
Main Authors: Croxtall, Jamie D., Dhillon, Sohita
Format: Article
Language:English
Subjects:
Adis Drug Evaluation
Adolescence
Adolescent
Adult
Age
Animals
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Bacteriology
Biological and medical sciences
Child
Child, Preschool
Children
Fundamental and applied biological sciences. Psychology
Hepatitis
Human bacterial diseases
Humans
Immune response
Immunogenicity
Immunological memory
Immunology
Infant
Infectious diseases
Internal Medicine
Invasive meningococcal disease
Medical sciences
Medicine
Medicine & Public Health
Meningitis
meningococcal disease
Meningococcal Infections - immunology
Meningococcal Infections - prevention & control
Meningococcal Vaccines - administration & dosage
Meningococcal Vaccines - immunology
Microbiology
Middle Aged
Neisseria meningitidis
Neisseria meningitidis - immunology
Pharmacology/Toxicology
Pharmacotherapy
Polysaccharides
Rabbits
Randomized Controlled Trials as Topic
Serum bactericidal activity
Serum Bactericidal Antibody Assay
Streptococcus infections
Teenagers
Tetanus
Tetanus Toxoid - administration & dosage
Tetanus Toxoid - immunology
Toddlers
Vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Combined - administration & dosage
Vaccines, Combined - immunology
Vaccines, Conjugate - administration & dosage
Vaccines, Conjugate - immunology
Young Adult
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Description
Summary:Nimenrix™ (MenACWY-TT) is a quadrivalent meningococcal conjugate vaccine, comprising the polysaccharide serogroups A, C, W135 and Y, and tetanus toxoid (TT) as carrier protein. It is the first quadrivalent vaccine (administered as a single dose) to be approved in Europe for active immunization of individuals aged ≥12 months against invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W135 and Y. Administration of a single dose of Nimenrix™ elicited a strong immune response against all four vaccine serogroups in healthy toddlers aged 12’23 months, children and adolescents aged 2’17 years and adults aged 18’55 years in randomized, multicentre, phase III trials. In toddlers, Nimenrix™ was noninferior to Meningitec® in terms of seroresponse rates against meningococcal serogroup C 42 days post-vaccination. In children, adolescents and adults, Nimenrix™ was noninferior to Mencevax™ in terms of vaccination response rates against all four serogroups 1 month post-vaccination. Furthermore, several phase II studies and a phase III trial showed that the immune response elicited by Nimenrix™ in all age groups persisted for 7–42 months after the primary vaccination (when evaluated by rabbit serum bactericidal activity), with the vaccine also inducing immune memory in toddlers. In addition, several randomized, multicentre, phase III, noninferiority trials showed that when coadministered with other childhood vaccines or a seasonal flu vaccine, the immunogenicity of Nimenrix™ or that of the coadministered vaccine was generally not altered. Nimenrix® was generally well tolerated in all age groups whether administered as a single vaccine or coadministered with other routine vaccines. The incidence of grade 3 local or systemic solicited adverse events during the first 4 days following vaccination and of serious adverse events over an extended follow-up period of up to 6 months was low (
ISSN:0012-6667
1179-1950
DOI:10.2165/11209580-000000000-00000