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Use of Electron Microscopy to Classify Canine Perivascular Wall Tumors
The histologic classification of canine perivascular wall tumors (PWTs) is controversial. Many PWTs are still classified as hemangiopericytomas (HEPs), and the distinction from peripheral nerve sheath tumors (PNSTs) is still under debate. A recent histologic classification of canine soft tissue sarc...
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Published in: | Veterinary pathology 2013-03, Vol.50 (2), p.226-233 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The histologic classification of canine perivascular wall tumors
(PWTs) is controversial. Many PWTs are still classified as
hemangiopericytomas (HEPs), and the distinction from peripheral
nerve sheath tumors (PNSTs) is still under debate. A recent
histologic classification of canine soft tissue sarcomas included most
histologic types of PWT but omitted those that were termed undifferentiated.
Twelve cases of undifferentiated canine PWTs were evaluated by transmission
electron microscopy. The ultrastructural findings supported a perivascular wall
origin for all cases with 4 categories of differentiation: myopericytic
(n = 4), myofibroblastic (n = 1),
fibroblastic (n = 2), and undifferentiated (n
= 5). A PNST was considered unlikely in each case based on
immunohistochemical expression of desmin and/or the lack of typical
ultrastructural features, such as basal lamina. Electron microscopy was pivotal
for the subclassification of canine PWTs, and the results support the hypothesis
that canine PWTs represent a continuum paralleling the phenotypic plasticity of
vascular mural cells. The hypothesis that a subgroup of PWTs could arise from a
pluripotent mesenchymal perivascular wall cell was also considered and may
explain the diverse differentiation of canine PWTs. |
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ISSN: | 0300-9858 1544-2217 |
DOI: | 10.1177/0300985812456213 |