Tumor B7-H1 and B7-H3 Expression in Squamous Cell Carcinoma of the Lung

Micro-Abstract Aberrant expression of immunomodulatory proteins B7-H1 and B7-H3 by malignant cells may contribute to tumoral immune evasion. Immunohistochemistry for B7-H1 and B7-H3 was performed on 214 resected pulmonary squamous cell carcinoma specimens: 42 of 214 (19.6%) were positive for B7-H1,...

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Bibliographic Details
Published in:Clinical lung cancer 2013-03, Vol.14 (2), p.157-163
Main Authors: Boland, Jennifer M, Kwon, Eugene D, Harrington, Susan M, Wampfler, Jason A, Tang, Hui, Yang, Ping, Aubry, Marie Christine
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
B7 Antigens - analysis
B7-H1
B7-H1 Antigen - analysis
B7-H3
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - pathology
Female
Hematology, Oncology and Palliative Medicine
Humans
Immunohistochemistry
Lung cancer
Lung Neoplasms - chemistry
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Male
Middle Aged
Neoplasm Staging
Pulmonary/Respiratory
Squamous cell carcinoma
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Summary:Micro-Abstract Aberrant expression of immunomodulatory proteins B7-H1 and B7-H3 by malignant cells may contribute to tumoral immune evasion. Immunohistochemistry for B7-H1 and B7-H3 was performed on 214 resected pulmonary squamous cell carcinoma specimens: 42 of 214 (19.6%) were positive for B7-H1, and 189 of 214 (88.3%) were positive for B7-H3. These markers do not have independent prognostic value but are commonly expressed by tumor cells in pulmonary squamous carcinomas.
ISSN:1525-7304
1938-0690
DOI:10.1016/j.cllc.2012.05.006