Predictors of residual viraemia in patients on long-term suppressive antiretroviral therapy

HIV-1-infected individuals with plasma RNA100,000 copies/ml and on-therapy RNA levels below detection limits of commercial assays for ≥ 6 months. Of 103 patients eligible for analysis, the median age was 46 years and the median duration of viral suppression was 4.8 years. 62% had detectable viraemia...

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Bibliographic Details
Published in:Antiviral therapy 2013, Vol.18 (1), p.39-43
Main Authors: LU ZHENG, BOSCH, Ronald J, CHAN, Ellen S, READ, Sarah, KEARNEY, Mary, MARGOLIS, David M, MELLORS, John W, ERON, Joseph J, GANDHI, Rajesh T
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active - methods
Antiviral agents
Biological and medical sciences
CD4 Lymphocyte Count
Drug Administration Schedule
Female
HIV Infections - drug therapy
HIV Infections - virology
HIV-1 - drug effects
HIV-1 - genetics
HIV-1 - physiology
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Polymerase Chain Reaction - methods
Predictive Value of Tests
RNA, Viral - blood
RNA, Viral - genetics
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Viremia - drug therapy
Viremia - virology
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Summary:HIV-1-infected individuals with plasma RNA100,000 copies/ml and on-therapy RNA levels below detection limits of commercial assays for ≥ 6 months. Of 103 patients eligible for analysis, the median age was 46 years and the median duration of viral suppression was 4.8 years. 62% had detectable viraemia (>0.2 copies/ml) by SCA (median 0.2 copies/ml, IQR 2 years (median 2.3 versus 0.2 copies/ml; P=0.016). Among HIV-1-infected patients with pre-ART HIV-1 RNA>100,000 copies/ml, residual viraemia was detectable in the majority (62%) despite many years of suppressive ART. Higher level viraemia was associated with older age and
ISSN:1359-6535
2040-2058
DOI:10.3851/IMP2323