ANT1 is reduced in sporadic inclusion body myositis

To investigate ANT1 and NF-κB expression in inclusion body myositis (IBM) muscle and to verify their possible roles in the pathogenesis of the disease, we collected muscle samples from five patients with IBM, polimyositis (PM) and controls. p65 form of NF-κB was analyzed using immunocytochemistry, W...

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Bibliographic Details
Published in:Neurological sciences 2013-02, Vol.34 (2), p.217-224
Main Authors: Barca, E., Aguennouz, M., Mazzeo, A., Messina, S., Toscano, A., Vita, G. L., Portaro, S., Parisi, D., Rodolico, C.
Format: Article
Language:English
Subjects:
Adenine Nucleotide Translocator 1 - metabolism
Aged
Aged, 80 and over
Apoptosis
Female
Gene expression
Humans
Immunocytochemistry
Inclusion bodies
Male
Medicine
Medicine & Public Health
Middle Aged
Mitochondria
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Muscles
Myositis
Myositis, Inclusion Body - metabolism
Myositis, Inclusion Body - pathology
Neurology
Neuroradiology
Neurosciences
Neurosurgery
NF- Kappa B protein
NF-kappa B - metabolism
Original Article
Overexpression
Polymyositis - metabolism
Polymyositis - pathology
Psychiatry
Western blotting
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Summary:To investigate ANT1 and NF-κB expression in inclusion body myositis (IBM) muscle and to verify their possible roles in the pathogenesis of the disease, we collected muscle samples from five patients with IBM, polimyositis (PM) and controls. p65 form of NF-κB was analyzed using immunocytochemistry, Western blot and EMSA. Western blot of ANT1 was performed and confirmed by gene expression study. Mann–Whitney test was used for groups comparisons. NF-κB (p65) was found over-expressed both with western blot and EMSA, either in IBM or PM patients versus controls ( p  
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-012-0976-2