Migraine is not associated with enhanced atherosclerosis

Aim Migraine, in particular with aura, has been associated with an increased risk for ischemic stroke and coronary heart disease. The underlying mechanism is unknown. In a cross-sectional case control study we investigated whether an enhanced risk of atherosclerosis in migraineurs explains this incr...

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Bibliographic Details
Published in:Cephalalgia 2013-03, Vol.33 (4), p.228-235
Main Authors: Stam, Anine H, Weller, Claudia M, Janssens, A Cecile JW, Aulchenko, Yurii S, Oostra, Ben A, Frants, Rune R, van den Maagdenberg, Arn MJM, Ferrari, Michel D, van Duijn, Cornelia M, Terwindt, Gisela M
Format: Article
Language:English
Subjects:
Ankle Brachial Index
Atherosclerosis - complications
Atherosclerosis - epidemiology
Carotid Intima-Media Thickness
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Migraine Disorders - complications
Prevalence
Pulse Wave Analysis
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Summary:Aim Migraine, in particular with aura, has been associated with an increased risk for ischemic stroke and coronary heart disease. The underlying mechanism is unknown. In a cross-sectional case control study we investigated whether an enhanced risk of atherosclerosis in migraineurs explains this increased cardiovascular risk. Methods Subjects were participants from the population-based Erasmus Rucphen Family study. Atherosclerosis was assessed in 360 migraineurs (209 without aura and 151 with aura) and 617 subjects without migraine or severe headache. Atherosclerosis was quantified by intima media thickness, pulse wave velocity and ankle-brachial index. Results Migraineurs, especially with aura, were found more likely to smoke, have diabetes or a modestly decreased HDL-cholesterol. No differences were found for the atherosclerosis parameters. Conclusion In this large population-based study, migraineurs have no increased risk of atherosclerosis. Therefore, enhanced atherosclerosis is an unlikely explanation for the increased cardiovascular risk seen in migraineurs.
ISSN:0333-1024
1468-2982
DOI:10.1177/0333102412466966