Substance P induces gastric mucosal protection at supraspinal level via increasing the level of endomorphin-2 in rats

Highlights ► Substance P via acting on central NK1–3 receptors induces gastroprotection. ► Endomorphin-2 is likely to play a role in the SP-induced gastroprotective effect. ► The centrally induced effect is mediated by the vagal nerve to the periphery. ► In the periphery prostaglandins, nitric oxide...

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Bibliographic Details
Published in:Brain research bulletin 2013-02, Vol.91, p.38-45
Main Authors: Brancati, Serena B, Zádori, Zoltán S, Németh, József, Gyires, Klára
Format: Article
Language:English
Subjects:
Alcohols - toxicity
Animals
Calcitonin gene-related peptide
Calcitonin Gene-Related Peptide - biosynthesis
Disease Models, Animal
Endomorphin
Ethanol - toxicity
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Gastric ulcer
Injections, Intraventricular
Male
Neurology
Neurotransmitter Agents - administration & dosage
Neurotransmitter Agents - metabolism
Oligopeptides - biosynthesis
Radioimmunoassay
Rats
Rats, Wistar
Stomach Ulcer - chemically induced
Stomach Ulcer - metabolism
Stomach Ulcer - pathology
Substance P
Substance P - administration & dosage
Substance P - metabolism
Tachykinins
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Summary:Highlights ► Substance P via acting on central NK1–3 receptors induces gastroprotection. ► Endomorphin-2 is likely to play a role in the SP-induced gastroprotective effect. ► The centrally induced effect is mediated by the vagal nerve to the periphery. ► In the periphery prostaglandins, nitric oxide and CGRP mediate the effect. ► Alterations in gastric motor activity do not contribute to the gastroprotection.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2013.01.004